Left atrial dysfunction as the major driver of heart failure with preserved ejection fraction syndrome

被引：10

作者：

Ovchinnikov, Artem G. ^{[1
,2
]}

Potekhina, Alexandra ^{[1
]}

Belyavskiy, Evgeny ^{[3
]}

Gvozdeva, Anna ^{[1
]}

Ageev, Fail ^{[1
]}

机构：

[1] Natl Med Res Ctr Cardiol, Inst Clin Cardiol, Out Patient Dept, 3-D Cherepkovskaya St,15a, Moscow 121552, Russia

[2] AI Yevdokimov Moscow State Univ Med & Dent, Dept Clin Funct Diagnost, Moscow, Russia

[3] Charite Univ Med Berlin, Dept Internal Med & Cardiol, Campus Virchow Klinikum, Univ Med Berlin, Berlin, Germany

来源：

JOURNAL OF CLINICAL ULTRASOUND | 2022年 / 50卷 / 08期

关键词：

diastolic dysfunction; echocardiography; heart failure with preserved ejection fraction; left atrial dysfunction; VENTRICULAR DIASTOLIC FUNCTION; SPECKLE-TRACKING ECHOCARDIOGRAPHY; GREATER-THAN-OR-EQUAL-TO-65; YEARS; DOPPLER-ECHOCARDIOGRAPHY; DILATED CARDIOMYOPATHY; SYSTOLIC DYSFUNCTION; FILLING PATTERN; LA STRAIN; VOLUME; FIBRILLATION;

D O I：

10.1002/jcu.23318

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Left atrial (LA) dysfunction seems to play a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), is associated with disease severity and poor outcomes and potentially impacts management. Identifying LA myopathy can help guide tailored therapy for HFpEF. Echocardiography allows the accurate measurement of atrial size and function, where LA strain appears to be a sensitive measure of intrinsic LA myopathy. Several therapies and devices that decompress of left atrium are being tested for HFpEF. Further investigation is required to understand the specific atrial effects of statins, mineralocorticoid receptor antagonists, and other therapies.

引用

页码：1073 / 1083

页数：11

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