Adults with early-onset obsessive-compulsive disorder

被引:271
作者
do Rosario-Campos, MC
Leckman, JF
Mercadante, MT
Shavitt, RG
Prado, HD
Sada, P
Zamignani, D
Miguel, EC
机构
[1] Yale Univ, Ctr Child Study, Sch Med, New Haven, CT 06520 USA
[2] Univ Sao Paulo, Sch Med, Dept Psychiat, BR-05508 Sao Paulo, Brazil
关键词
D O I
10.1176/appi.ajp.158.11.1899
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder with a bimodal age at onset and range of treatment outcomes. This study attempted to ascertain the importance of the age at OCD symptom onset for a better phenotypic precision. Therefore, the authors compared adult OCD patients with an early symptom onset to OCD patients with a later symptom onset. Method: Forty-two adult outpatients with OCD were evaluated with semistructured interviews: 21 with symptom onset before the age of 10 (early-onset group) and 21 with symptom onset after the age of 17 (late-onset group). Results: Early onset was associated with higher scores on the Yale-Brown Obsessive Compulsive Scale, higher frequencies of tic-like compulsions, higher frequency of sensory phenomena, and a higher rate of comorbid tic disorders. The early-onset group also responded less well to treatment with clomipramine and selective serotonin reuptake inhibitors. Conclusions: The results indicate that age at onset may be an important factor in subtyping OCD and that the phenotypic differences found were not restricted to childhood.
引用
收藏
页码:1899 / 1903
页数:5
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