Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus

被引：34
作者：
Du Jian-ling [1 ,2 ]
Sun Chang-kai [3 ,4 ]
Lue Bo [2 ]
Men Li-li [2 ]
Yao Jun-jie [2 ]
An Li-jia [1 ]
Song Gui-rong [5 ]
机构：
[1] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116023, Liaoning, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dept Endocrinol, Dalian 116011, Liaoning, Peoples R China
[3] Dalian Med Univ, Inst Brain Disorders, Dalian 116044, Liaoning, Peoples R China
[4] Dalian Med Univ, Key Lab Brain Disorders Liaoning Prov, Dalian 116044, Liaoning, Peoples R China
[5] Dalian Med Univ, Dept Hlth Stat, Dalian 116044, Liaoning, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2008年 / 121卷 / 13期
关键词：
tanis/SelS; serum amyloid A; insulin resistance; type 2 diabetes mellitus;
D O I：
10.1097/00029330-200807010-00003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats (Psammomys obesus, Israeli sand rat) and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM), and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level. Methods Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction (PCR), Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay (ELISA). Results SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group. Conclusions SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.
引用
收藏
页码：1165 / 1168
页数：4
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