New lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#

被引：22

作者：

Huang, Jiguo ^{[1
,2
]}

Xu, Jiayi ^{[1
]}

Wang, Zhen ^{[4
]}

Khan, Dilfaraz ^{[1
]}

Niaz, Shah Iram ^{[1
]}

Zhu, Yonghong ^{[4
]}

Lin, Yongcheng ^{[3
]}

Li, Jing ^{[1
,2
]}

Liu, Lan ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, South China Sea Resource Exploitat & Protect Coll, Guangzhou, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Histol & Embryol, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 03期

基金：

美国国家科学基金会;

关键词：

Mangrove endophytic fungus; Lasiodiplodia; lasiodiplodins; TUMOR-PROMOTING ACTIVITY; EXCOECARIA-AGALLOCHA; DERIVATIVES; THEOBROMAE; LACTONES;

D O I：

10.1080/14786419.2016.1239096

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new lasiodiplodins (1-2) together with three known analogues, were isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318(#). Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds 1-5 were evaluated in vitro. Compound 4 was the most potent, with IC50 values of 5.29M against MMQ, 13.05M against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities. [GRAPHICS] .

引用

页码：326 / 332

页数：7

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