Rhodium-Catalyzed Asymmetric Arylation of N-(tert-Butanesulfinyl)imines with Sodium Tetraarylborates

被引：27

作者：

Reddy, Leleti Rajender ^{[1
]}

Gupta, Aditya P. ^{[1
]}

Villhauer, Eric ^{[1
]}

Liu, Yugang ^{[1
]}

机构：

[1] Novartis Pharmaceut, Chem & Analyt Dev, E Hanover, NJ 07936 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 02期

关键词：

N-TERT-BUTANESULFINYL; ARYLBORONIC ACIDS; ENANTIOSELECTIVE SYNTHESIS; ORGANOMETALLIC REAGENTS; CYTOKINE MODULATOR; IMINES; TOSYLARYLIMINES; LEVOCETIRIZINE; ADDITIONS; AMINES;

D O I：

10.1021/jo2024224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl)imines with sodium tetraarylborates is described. This method is general for constructing various chiral alpha-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.

引用

页码：1095 / 1100

页数：6

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