Trends in vanadium neurotoxicity

被引：45
作者：
Fatola, Olanrewaju I. [1 ]
Olaolorun, Francis A. [1 ]
Olopade, Funmilayo E. [2 ]
Olopade, James O. [1 ]
机构：
[1] Univ Ibadan, Dept Vet Anat, Ibadan, Nigeria
[2] Univ Ibadan, Dept Anat, Ibadan, Nigeria
来源：
BRAIN RESEARCH BULLETIN | 2019年 / 145卷
关键词：
Vanadium; Environmental pollution; Neurotoxicity; Neurodegeneration; HYDROXYL RADICAL GENERATION; INSULIN-LIKE ACTIONS; IN-VIVO; VANADATE; MECHANISMS; INHALATION; TOXICITY; CANCER; PROLIFERATION; PREVENTION;
D O I：
10.1016/j.brainresbull.2018.03.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Vanadium, atomic number 23, is a transition metal widely distributed in nature. It is a major contaminant of fossil fuels and is widely used in industry as catalysts, in welding, and making steel alloys. Over the years, vanadium compounds have been generating interests due to their use as therapeutic agents in the control of diabetes, tuberculosis, and some neoplasms. However, the toxicity of vanadium compounds is well documented in literature with occupational exposure of workers in vanadium allied industries, environmental pollution from combustion of fossil fuels and industrial exhausts receiving concerns as major sources of toxicity and a likely predisposing factor in the aetiopathogenesis of neurodegenerative diseases. A lot has been done to understand the neurotoxic effects of vanadium, its mechanisms of action and possible antidotes. Sequel to our review of the subject in 2011, this present review is to detail the recent insights gained in vanadium neurotoxicity.
引用
收藏
页码：75 / 80
页数：6
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