Echocardiographic Assessment of Cardiac Structural and Functional Abnormalities in Patients With End-Stage Renal Disease Receiving Chronic Hemodialysis

被引：40

作者：

Matsuo, Hiroshi ^{[1
]}

Dohi, Kaoru ^{[1
]}

Machida, Hirofumi ^{[3
]}

Takeuchi, Hideyuki ^{[3
]}

Aoki, Toshikazu ^{[4
]}

Nishimura, Hiroyuki ^{[4
]}

Yasutomi, Masashi ^{[5
]}

Senga, Michiharu ^{[6
]}

Ichikawa, Takehiko ^{[6
]}

Kakuta, Kentaro ^{[7
]}

Mizutani, Yasuhide ^{[8
]}

Tanoue, Akiko ^{[9
]}

Isaka, Naoki ^{[9
]}

Oosugi, Kazuki ^{[10
]}

Koyabu, Sukenari ^{[10
]}

Sakurai, Masato ^{[11
]}

Fukui, Yoshihisa ^{[11
]}

Kakimoto, Hitoshi ^{[11
]}

Sugimoto, Tadafumi ^{[12
]}

Ohnishi, Takahiro ^{[13
]}

Murata, Tomohiro ^{[1
,14
]}

Ishikawa, Eiji ^{[1
,14
]}

Okamoto, Ryuji ^{[1
]}

Yamada, Tomomi ^{[2
]}

Ogura, Toru ^{[15
]}

Nishimura, Yuki ^{[15
]}

Tanigawa, Takashi ^{[1
]}

Nomura, Shinsuke ^{[1
,14
]}

Nishikawa, Masakatsu ^{[16
]}

Ito, Masaaki ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Cardiol & Nephrol, 2-174 Edobashi, Tsu, Mie 5148507, Japan

[2] Mie Univ, Grad Sch Med, Dept Translat Med Sci, Tsu, Mie, Japan

[3] Takeuchi Hosp, Dept Internal Med, Tsu, Mie, Japan

[4] Tohyama Hosp, Dept Internal Med, Tsu, Mie, Japan

[5] Kuwana City Med Ctr, Dept Nephrol, Kuwana, Japan

[6] Kuwana City Med Ctr, Dept Cardiol, Kuwana, Japan

[7] Yokkaichi Hazu Med Ctr, Dept Cardiol, Yokaichi, Japan

[8] Yokkaichi Hazu Med Ctr, Dept Nephrol, Yokaichi, Japan

[9] Murase Hosp, Dept Internal Med, Suzuka, Japan

[10] Owase Gen Hosp, Dept Internal Med, Owase, Japan

[11] Saiseikai Matsusaka Gen Hosp, Dept Internal Med, Matsusaka, Japan

[12] Ise Red Cross Hosp, Dept Cardiol, Ise, Japan

[13] Ise Red Cross Hosp, Dept Nephrol, Ise, Japan

[14] Mie Univ Hosp, Div Hemodialysis Ctr, Tsu, Mie, Japan

[15] Mie Univ Hosp, Clin Res Support Ctr, Tsu, Mie, Japan

[16] Mie Univ, Fac Med, Inst Human Res Promot & Drug Dev, Tsu, Mie, Japan

来源：

CIRCULATION JOURNAL | 2018年 / 82卷 / 02期

关键词：

Aortic valve sclerosis; Echocardiography; End-stage renal disease; Hemodialysis; Left ventricle; LEFT-VENTRICULAR HYPERTROPHY; AORTIC-VALVE CALCIFICATION; FREQUENT HEMODIALYSIS; DIASTOLIC DYSFUNCTION; EJECTION FRACTION; AMERICAN-SOCIETY; STENOSIS; RECOMMENDATIONS; DETERMINANTS; AFTERLOAD;

D O I：

10.1253/circj.CJ-17-0393

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The aim of this study was to assess the echocardiographic characteristics of chronic hemodialysis (HD) patients with end-stage renal disease (ESRD) in a multicenter prospective cohort study. Methods and Results: Three hundred and fifteen patients with ESRD (67.9 +/- 10.6 years, 47.6% male) on chronic HD for >= 1 year were examined on transthoracic echocardiography, including Doppler-derived aortic valve area (AVA) measurement. Only 11.5% and 3.4% of all patients had normal left ventricular (LV) geometry and normal LV filling pattern, respectively. The majority of patients had aortic and mitral valvular calcification, and approximately 50% of all 315 patients had aortic valve narrowing with AVA <2.0 cm(2). Patients were divided into 3 groups according to AVA index tertile: group 1, highest tertile; group 2, middle tertile; and group 3, lowest tertile. Group 3 was older, had a greater cardiothoracic ratio on chest X-ray, higher plasma brain natriuretic peptide and total LV afterload, and lower stroke volume index than the other 2 groups. Age and intact parathyroid hormone (PTH) level were independently associated with low AVA index. Conclusions: Patients with ESRD on chronic HD have a high prevalence of cardiac structural and functional abnormalities including calcified aortic sclerosis. High age and PTH were associated with aortic valve narrowing in these patients.

引用

页码：586 / +

页数：12

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