PEG modified trimethyl chitosan based nanoparticles for the codelivery of doxorubicin and iSur-pDNA

被引：9

作者：

Mai, Qi ^{[1
]}

Shen, Suqin ^{[1
]}

Liu, Yifu ^{[1
]}

Tang, Cui ^{[1
]}

Yin, Chunhua ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, Shanghai 200438, Peoples R China

来源：

MATERIALS LETTERS | 2019年 / 238卷

关键词：

Nanoparticles; Polymers; PEG modification; Codelivery; Antitumor efficacy; DELIVERY;

D O I：

10.1016/j.matlet.2018.11.161

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Doxorubicin (DOX) is one of the commonly used chemotherapeutic agents, but its clinical use is restricted by systemic toxicity and tumor multidrug resistance. To overcome these barriers, PEG modified trimethyl chitosan based nanoparticles (NPs) were prepared for the coencapsulation and codelivery of DOX and survivin shRNA-expressing plasmid (iSur-pDNA). These NPs with particle sizes of 181.9 nm and zeta potentials of 20.2 mV exhibited a pH-sensitive release of DOX and a sustained release of iSur-pDNA, which exerted significantly enhanced in vivo antitumor efficacies compared with single administration with DOX or iSur-pDNA. The results indicated that combinational administration of chemotherapeutic drugs and genes based on NPs could be promising in cancer therapy. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：143 / 146

页数：4

共 10 条

[1] Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology [J].

Bertrand, Nicolas ;

Wu, Jun ;

Xu, Xiaoyang ;

Kamaly, Nazila ;

Farokhzad, Omid C. .

ADVANCED DRUG DELIVERY REVIEWS, 2014, 66 :2-25

[2] In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery [J].

Chen, Fu ;

Zhang, Zhi-Rong ;

Yuan, Fang ;

Qin, Xuan ;

Wang, Minting ;

Huang, Yuan .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 349 (1-2) :226-233

[3] Co-Delivery of Doxorubicin and siRNA with Reduction and pH Dually Sensitive Nanocarrier for Synergistic Cancer Therapy [J].

Chen, Weicai ;

Yuan, Yuanyuan ;

Cheng, Du ;

Chen, Jifeng ;

Wang, Lu ;

Shuai, Xintao .

SMALL, 2014, 10 (13) :2678-2687

[4] A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery [J].

Du, Changli ;

Deng, Dawei ;

Shan, Lingling ;

Wan, Shunan ;

Cao, Jie ;

Tian, Junmei ;

Achilefu, Samuel ;

Gu, Yueqing .

BIOMATERIALS, 2013, 34 (12) :3087-3097

[5] The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect [J].

Fang, Jun ;

Nakamura, Hideaki ;

Maeda, Hiroshi .

ADVANCED DRUG DELIVERY REVIEWS, 2011, 63 (03) :136-151

[6] Synthesis, characterization, antitumor activity of pluronic mimicking copolymer micelles conjugated with doxorubicin via acid-cleavable linkage [J].

Lee, Yuhan ;

Park, Sung Young ;

Mok, Hyejung ;

Park, Tae Gwan .

BIOCONJUGATE CHEMISTRY, 2008, 19 (02) :525-531

[7] Strategies in the design of nanoparticles for therapeutic applications [J].

Petros, Robby A. ;

DeSimone, Joseph M. .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (08) :615-627

[8] Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery [J].

Yin, Lichen ;

Ding, Jieying ;

He, Chunbai ;

Cui, Liming ;

Tang, Cui ;

Yin, Chunhua .

BIOMATERIALS, 2009, 30 (29) :5691-5700

[9] Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy [J].

Zheng, Hao ;

Tang, Cui ;

Yin, Chunhua .

BIOMATERIALS, 2015, 70 :126-137

[10] PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation [J].

Zhu, Saijie ;

Hong, Minghuang ;

Zhang, Lihong ;

Tang, Guotao ;

Jiang, Yanyan ;

Pei, Yuanying .

PHARMACEUTICAL RESEARCH, 2010, 27 (01) :161-174

← 1 →