HIV-1 capsid: the multifaceted key player in HIV-1 infection

被引：310

作者：

Campbell, Edward M. ^{[1
]}

Hope, Thomas J. ^{[2
]}

机构：

[1] Loyola Univ Chicago, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 08期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; NUCLEAR-PORE COMPLEX; REVERSE TRANSCRIPTION COMPLEXES; COMPLEMENTARY ASSAYS REVEAL; CYCLOSPORINE-A-RESISTANT; CYCLOPHILIN-A; PREINTEGRATION COMPLEXES; CDNA INTEGRATION; CELLULAR FACTORS; TERMINAL DOMAIN;

D O I：

10.1038/nrmicro3503

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core made from the viral capsid (CA) protein. The CA protein and the structure into which it assembles facilitate virtually every step of infection through a series of interactions with multiple host cell factors. This Review describes our understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. We then discuss how elucidating these interactions can reveal new targets for therapeutic interactions against HIV-1.

引用

页码：471 / 483

页数：13

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