MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy

被引：75

作者：

Dahlqvist, Julia R. ^{[1
]}

Widholm, Per ^{[2
,3
]}

Leinhard, Olof Dahlqvist ^{[2
,3
]}

Vissing, John ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Neurol, Copenhagen Neuromuscular Ctr, Rigshosp, Sect 3342,Blegdamsvej 9, DK-2100 Copenhagen, Denmark

[2] Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden

[3] AMRA Med AB, Linkoping, Sweden

来源：

ANNALS OF NEUROLOGY | 2020年 / 88卷 / 04期

关键词：

DUCHENNE MUSCULAR-DYSTROPHY; QUANTITATIVE MUSCLE MRI; FATTY INFILTRATION; SKELETAL-MUSCLE; RELAXATION-TIME; OUTCOME MEASURE; CLINICAL-TRIAL; IMAGE SLICE; BOYS; STRENGTH;

D O I：

10.1002/ana.25804

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is an unmet need to identify biomarkers sensitive to change in rare, slowly progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of muscle may offer this opportunity, as it is noninvasive and can be carried out almost independent of patient cooperation and disease severity. Muscle fat content correlates with muscle function in neuromuscular diseases, and changes in fat content precede changes in function, which suggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment efficacy. In this paper, we review the evidence suggesting that muscle MRI may be an important biomarker for diagnosis and to monitor change in disease severity. ANN NEUROL 2020

引用

页码：669 / 681

页数：13

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