Influence of physical properties of carrier on the performance of dry powder inhalers

被引：133

作者：

Peng, Tingting ^{[1
]}

Lin, Shiqi ^{[1
]}

Niu, Boyi ^{[1
]}

Wang, Xinyi ^{[1
]}

Huang, Ying ^{[1
]}

Zhang, Xuejuan ^{[1
]}

Li, Ge ^{[2
]}

Pan, Xin ^{[1
]}

Wu, Chuanbin ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangzhou Neworld Pharm Co Ltd, Guangzhou 51006, Guangdong, Peoples R China

[3] Guangdong Res Ctr Drug Delivery Syst, Guangzhou 510006, Guangdong, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2016年 / 6卷 / 04期

关键词：

Carrier; Particle size; Morphology; Surface roughness; Performance; Dry powder inhaler; SPRAY-DRIED MANNITOL; PULMONARY DRUG-DELIVERY; MODIFIED GLASS-BEADS; SALBUTAMOL SULFATE; IN-VITRO; FLUTICASONE PROPIONATE; AEROSOL PERFORMANCE; RELATIVE-HUMIDITY; SURFACE CHARACTERISTICS; PARTICLE FORMULATION;

D O I：

10.1016/j.apsb.2016.03.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dry powder inhalers (DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance. The purpose of this review is to summarize and illuminate how these factors affect drug carrier interaction and influence the performance of DPIs. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：308 / 318

页数：11

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