Serum copper-to-zinc-ratio and risk of incident infection in men: the Kuopio Ischaemic Heart Disease Risk Factor Study

被引:31
作者
Laine, Jaakko T. [1 ]
Tuomainen, Tomi-Pekka [1 ]
Salonen, Jukka T. [2 ,3 ]
Virtanen, Jyrki K. [1 ]
机构
[1] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, POB 1627, Kuopio 70211, Finland
[2] Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland
[3] MAS Metab Analyt Serv Oy, Helsinki, Finland
基金
美国国家卫生研究院; 芬兰科学院;
关键词
Copper; Zinc; Infections; Population study; Prospective study; MYOCARDIAL-INFARCTION; PLASMA ZINC; IMMUNE; SUPPLEMENTATION; MAGNESIUM; METALS; IMPACT;
D O I
10.1007/s10654-020-00644-1
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Infections are one of the main causes of mortality in elderly due to the decrease of immune response, for which copper (Cu) and zinc (Zn) are claimed to be crucial. High serum copper-to-zinc-ratio (Cu/Zn-ratio) has been reported with infections, but little is known whether it could also predict the incidence of infections. The study cohort consisted of 1975 men aged 42-60 years and free of severe infectious disease at baseline in 1984-1989 from the prospective population-based Kuopio Ischaemic & xfeff; Heart Disease Risk Factor Study. The main outcome was an incident infection leading to hospitalization. Cox proportional hazards regression models were used for statistical analysis. During the average follow-up of 19.2 years, 636 incident first cases of infections were diagnosed. The hazard ratio (HR) of developing an incident infectious disease in the highest compared to the lowest Cu/Zn-ratio quartile after adjustment for age and baseline examination year was 1.35 [95% confidence interval (CI) = 1.07-1.69, P-trend across quartiles = 0.005]. The association was slightly attenuated after additional adjustment for potential confounders (HR = 1.21, 95% CI = 0.96-1.53, P-trend = 0.054). Furthermore, higher serum Cu concentration was associated with higher risk of an incident infection. The multivariable-adjusted HR was 1.39 (95% CI = 1.10-1.75, P-trend = 0.005) in the highest versus the lowest serum Cu quartile. Serum Zn concentration was not associated with the risk (multivariable-adjusted extreme-quartile HR = 0.83, 95% CI = 0.67-1.04, P-trend = 0.218). In conclusion, our data suggest that an increased Cu/Zn-ratio and especially serum Cu concentration are associated with increased risk of incident infections in middle-aged and older men in Eastern Finland.
引用
收藏
页码:1149 / 1156
页数:8
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