In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis

被引：0

作者：

Rodrigues dos Santos Lima, Luciana Alves ^{[1
]}

Johann, Susana ^{[2
]}

Cisalpino, Patricia Silva ^{[2
]}

Santos Pimenta, Lucia Pinheiro ^{[3
]}

Diamantino Boaventura, Maria Amelia ^{[3
]}

机构：

[1] Univ Fed Sao Joao Del Rei, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Microbiol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Quim, Belo Horizonte, MG, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2011年 / 44卷 / 06期

关键词：

Fatty acid methyl esters; Antifungal activity; Paracoccidioides brasiliensis; TRIMETHOPRIM; RESISTANCE; AGENTS;

D O I：

暂无

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties. Methods: Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest. Results: In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum. Conclusions: FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.

引用

页码：777 / 780

页数：4

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