Risk of Non-melanoma Skin Cancer in Patients with Chronic Kidney Disease and its Relationship to Uraemic Pruritus

被引：16

作者：

Wang, Chia-Chen ^{[1
,2
,3
]}

Tang, Chao-Hsiun ^{[4
]}

Huang, Siao-Yuan ^{[4
]}

Huang, Kuan-Chih ^{[4
]}

Sue, Yuh-Mou ^{[5
,6
]}

机构：

[1] Cardinal Tien Hosp, Dept Dermatol, New Taipei, Taiwan

[2] Cardinal Tien Hosp, Dept Med Res, New Taipei, Taiwan

[3] Fu Jen Catholic Univ, Sch Med, New Taipei, Taiwan

[4] Taipei Med Univ, Coll Management, Sch Hlth Care Adm, Taipei, Taiwan

[5] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Nephrol, 5th Floor,111,Sect 3,Xing Long Rd, Taipei 116, Taiwan

[6] Taipei Med Univ, Sch Med, Div Nephrol, Coll Med,Dept Internal Med, Taipei, Taiwan

来源：

ACTA DERMATO-VENEREOLOGICA | 2017年 / 97卷 / 10期

关键词：

non-melanoma skin cancer; chronic kidney disease; uraemic pruritus; epidemiology; POPULATION-BASED COHORT; CKD; INFLAMMATION; HEMODIALYSIS; ASSOCIATION; NATIONWIDE; DIALYSIS; SYSTEM; DAMAGE;

D O I：

10.2340/00015555-2762

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Compared with the general population, a 1.14-fold risk of NMSC was found in the CKD cohort. NMSC risk was significant in patients with pre-dialysis stage 5 CKD and anaemia (1.48-fold), and in those with uraemic pruritus after long-term antihistamine treatment (1.38-fold). A higher SIR for NMSC was found in younger patients with CKD (age < 70 years, 1.34-fold; age 20-39 years, 1.63-fold), stage 5 CKD with anaemia (age < 70 years, 2.09-fold), and uraemic pruritus (age < 70 years, 2.22-fold). Pre-dialysis patients with CKD are at higher risk of NMSC, especially those with advanced-stage CKD, and those with uraemic pruritus.

引用

页码：1230 / 1234

页数：5

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