Layer-by-layer capsules for magnetic resonance imaging and drug delivery

被引:162
作者
Ai, Hua [1 ,2 ]
机构
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[2] Sichuan Univ, W China Hosp, Dept Radiol, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
Layer-by-layer; Self-assembly; Polyelectrolyte capsule; Magnetic resonance imaging; Paramagnetic; Superparamagnetic; Gadolinium; Iron oxide; Drug delivery; Molecular imaging; MRI CONTRAST AGENTS; FUNCTIONAL CORE/SHELL NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; IRON-OXIDE NANOPARTICLES; IN-VIVO; GD-DTPA; POLYELECTROLYTE MICROCAPSULES; BIOMEDICAL APPLICATIONS; HIGH-RELAXIVITY; GD3+-DIETHYLENETRIAMINEPENTAACETIC ACID;
D O I
10.1016/j.addr.2011.03.013
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their unique advantages and capability in drug delivery applications. These ordered micro/nano-structures are also promising candidates as imaging contrast agents for diagnostic and theranostic applications. Magnetic resonance imaging (MRI), one of the most powerful clinical imaging modalities, is moving forward to the molecular imaging field and requires the availability of advanced imaging probes. In this review, we are focusing on the design of MRI visible LbL capsules, which incorporate either paramagnetic metal-ligand complexes or superparamagnetic iron oxide (SPIO) nanoparticles. The design criteria cover the topics of probe sensitivity, biosafety, long-circulation property, targeting ligand decoration, and drug loading strategies. Examples of MRI visible LbL capsules with paramagnetic or superparamagnetic moieties were given and discussed. This carrier platform can also be chosen for other imaging modalities. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:772 / 788
页数:17
相关论文
共 228 条
[1]   Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI [J].
Accardo, Antonella ;
Tesauro, Diego ;
Aloj, Luigi ;
Pedone, Carlo ;
Morelli, Giancarlo .
COORDINATION CHEMISTRY REVIEWS, 2009, 253 (17-18) :2193-2213
[2]   Evaluation of maleimide derivative of DOTA for site-specific labeling of recombinant affibody molecules [J].
Ahlgren, Sara ;
Orlova, Anna ;
Rosik, Daniel ;
Sandstrom, Mattias ;
Sjoberg, Anna ;
Basstrup, Barbo ;
Widmark, Olof ;
Fant, Gunilla ;
Feldwisch, Joachim ;
Tolmachev, Vladimir .
BIOCONJUGATE CHEMISTRY, 2008, 19 (01) :235-243
[3]   Biomedical applications of electrostatic layer-by-layer nano-assembly of polymers, enzymes, and nanoparticles [J].
Ai, H ;
Jones, SA ;
Lvov, YM .
CELL BIOCHEMISTRY AND BIOPHYSICS, 2003, 39 (01) :23-43
[4]   Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes [J].
Ai, H ;
Flask, C ;
Weinberg, B ;
Shuai, X ;
Pagel, MD ;
Farrell, D ;
Duerk, J ;
Gao, JM .
ADVANCED MATERIALS, 2005, 17 (16) :1949-+
[5]   Interactions between self-assembled polyelectrolyte shells and tumor cells [J].
Ai, H ;
Pink, JJ ;
Shuai, XT ;
Boothman, DA ;
Gao, JM .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 73A (03) :303-312
[6]   Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly [J].
Ai, H ;
Gao, J .
JOURNAL OF MATERIALS SCIENCE, 2004, 39 (04) :1429-1432
[7]   Electrostatic layer-by-layer nanoassembly on biological microtemplates: Platelets [J].
Ai, H ;
Fang, M ;
Jones, SA ;
Lvov, YM .
BIOMACROMOLECULES, 2002, 3 (03) :560-564
[8]   Nano-encapsulation of furosemide microcrystals for controlled drug release [J].
Ai, H ;
Jones, SA ;
de Villiers, MM ;
Lvov, YM .
JOURNAL OF CONTROLLED RELEASE, 2003, 86 (01) :59-68
[9]  
Ai H., 2008, BOTTOM UP NANOFABRIC, P224
[10]  
Ai H., 2008, BIOMATERIALS FABRICA, P237