Arylation of Adamantanamines: VIII.1 Optimization of the Catalytic System for Copper-Catalyzed Arylation of Adamantane-Containing Amines

被引：11

作者：

Panchenko, S. P. ^{[1
]}

Abel, A. S. ^{[1
]}

Averin, A. D. ^{[1
,2
]}

Maloshitskaya, O. A. ^{[1
]}

Savelyev, E. N. ^{[3
]}

Orlinson, B. S. ^{[3
]}

Novakov, I. A. ^{[3
]}

Beletskaya, I. P. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Leninskie Gory 1-3, Moscow 119991, Russia

[2] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Leninskii Pr 31-4, Moscow 119071, Russia

[3] Volgograd State Tech Univ, Pr Lenina 28, Volgograd 400005, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 53卷 / 10期

基金：

俄罗斯基础研究基金会; 俄罗斯科学基金会;

关键词：

ISOMERIC CHLOROQUINOLINES; AMINATION; DERIVATIVES; SERIES; DIHALOBENZENES; INHIBITORS; DISCOVERY; DIAMINES; ANALOGS;

D O I：

10.1134/S1070428017100025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arylation of adamantane-containing amines with iodobenzene in the presence of copper(I) and copper(II) compounds and various N,N-, N,O-, and O,O-bidentate ligands was studied. The best results were obtained using the catalytic system CuI-rac-BINOL [1,1'-bi(naphthalen-2-ol)] (10/20 mol %). Reactions with iodobenzene derivatives containing electron-donor and electron-withdrawing substituents in the para position to the iodine atom were carried out under the optimal conditions.

引用

页码：1497 / 1504

页数：8

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