How do mesenchymal stromal cells suppress T cells?

被引：86
作者：
Keating, Armand [1 ]
机构：
[1] Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada
来源：
CELL STEM CELL | 2008年 / 2卷 / 02期
关键词：
D O I：
10.1016/j.stem.2008.01.007
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Accumulating information indicates that mesenchymal stem or stromal cells (MSCs) are immunomodulatory, but the data to explain the observations are frequently conflicting. In this issue of Cell Stem Cell, Ren et al. (2008) provide evidence for a possible underlying mechanism of MSC-mediated T cell suppression. A perspective for considering these interesting observations is discussed.
引用
收藏
页码：106 / 108
页数：3
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  • [1] Nitric oxide in immunity and inflammation
    Coleman, JW
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2001, 1 (08) : 1397 - 1406
  • [2] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    Di Nicola, M
    Carlo-Stella, C
    Magni, M
    Milanesi, M
    Longoni, PD
    Matteucci, P
    Grisanti, S
    Gianni, AM
    [J]. BLOOD, 2002, 99 (10) : 3838 - 3843
  • [3] Clarification of the nomenclature for MSC: The international society for cellular therapy position statement
    Horwitz, EM
    Le Blanc, K
    Dominici, M
    Mueller, I
    Slaper-Cortenbach, I
    Marini, FC
    Deans, RJ
    Krause, DS
    Keating, A
    [J]. CYTOTHERAPY, 2005, 7 (05) : 393 - 395
  • [4] Mesenchymal stromal cells
    Keating, Armand
    [J]. CURRENT OPINION IN HEMATOLOGY, 2006, 13 (06) : 419 - 425
  • [5] Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    Krampera, M
    Glennie, S
    Dyson, J
    Scott, D
    Laylor, R
    Simpson, E
    Dazzi, F
    [J]. BLOOD, 2003, 101 (09) : 3722 - 3729
  • [6] Hnmunomodulatory properties of mesenchymal stromal cells
    Nauta, Alma J.
    Fibbe, Willem E.
    [J]. BLOOD, 2007, 110 (10) : 3499 - 3506
  • [7] Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    Rasmusson, I
    Ringdén, O
    Sundberg, B
    Le Blanc, K
    [J]. EXPERIMENTAL CELL RESEARCH, 2005, 305 (01) : 33 - 41
  • [8] Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Ren, Guangwen
    Zhang, Liying
    Zhao, Xin
    Xu, Guangwu
    Zhang, Yingyu
    Roberts, Arthur I.
    Zhao, Robert Chunhua
    Shi, Yufang
    [J]. CELL STEM CELL, 2008, 2 (02) : 141 - 150
  • [9] Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    Sato, Kazuya
    Ozaki, Katsutoshi
    Oh, Iekuni
    Meguro, Akiko
    Hatanaka, Keiko
    Nagai, Tadashi
    Muroi, Kazuo
    Ozawa, Keiya
    [J]. BLOOD, 2007, 109 (01) : 228 - 234
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