Caveolin-1: A tumor-promoting role in human cancer

被引：107
作者：
Shatz, Maria [1 ]
Liscovitch, Mordechai [1 ]
机构：
[1] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel
来源：
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2008年 / 84卷 / 03期
关键词：
cancer; caveolin-1; cell survival; multidrug resistance; prostate cancer; signal transduction;
D O I：
10.1080/09553000701745293
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Purpose: Caveolae are non-clathrin, flask-shaped invaginations of the plasma membrane. Caveolin-l is an essential constituent of caveolae and as such acts as a regulator of caveolae-dependent lipid trafficking and endocytosis. Caveolin-1 interacts with a variety of cellular proteins and regulates cell-signaling events. Caveolin-l appears to act as a tumor suppressor protein at early stages of cancer progression. However, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. Furthermore, caveolin-1 levels are positively correlated with tumor stage and grade in numerous cancer types. Conclusion: The available experimental data support the tumor-promoting role of caveolin-1 in advanced-stage cancer.
引用
收藏
页码：177 / 189
页数：13
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