SLAM Family Receptors and SAP Adaptors in Immunity

被引：384

作者：

Cannons, Jennifer L. ^{[1
]}

Tangye, Stuart G. ^{[2
]}

Schwartzberg, Pamela L. ^{[1
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] Garvan Inst Med Res, Program Immunol, Darlinghurst, NSW 2010, Australia

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 | 2011年 / 29卷

关键词：

XLP; cytotoxicity; germinal centers; autoimmunity; innate lymphocytes; LINKED LYMPHOPROLIFERATIVE-DISEASE; LYMPHOCYTIC ACTIVATION MOLECULE; NATURAL-KILLER-CELLS; GENE-PRODUCT SAP; CD4(+) T-CELLS; MEMORY B-CELLS; THYMOCYTE-THYMOCYTE INTERACTION; PROTEIN-TYROSINE-PHOSPHATASE; BONE-MARROW-TRANSPLANTATION; DOMAIN-CONTAINING PROTEINS;

D O I：

10.1146/annurev-immunol-030409-101302

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists almost entirely of a single SH2 protein domain that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84, Ly9, and potentially CRACC. SLAM family members are now recognized as important immunomodulatory receptors with roles in cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte development, and cell adhesion. In this review, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, with a focus on their regulation of the pathways involved in the pathogenesis of XLP and other immune disorders.

引用

页码：665 / 705

页数：41

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