Adaptive biased-coin designs for skewing the allocation proportion in clinical trials with normal responses

被引：33
作者：
Atkinson, AC
Biswas, A
机构：
[1] London Sch Econ, Dept Stat, London WC2A 2AE, England
[2] Indian Stat Inst, Appl Stat Unit, Kolkata 700108, India
来源：
STATISTICS IN MEDICINE | 2005年 / 24卷 / 16期
关键词：
50 : 50 allocation; D-A-optimal design; ethics; inference; limiting proportion of allocation; minimization; randomization; regularization;
D O I：
10.1002/sim.2124
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments. The adaptive design does not affect inference. Copyright (C) 2005 John Wiley & Sons, Ltd.
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页码：2477 / 2492
页数：16
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