Hijacking of the AP-1 Signaling Pathway during Development of ATL

被引:172
作者
Gazon, Helene [1 ]
Barbeau, Benoit [2 ,3 ]
Mesnard, Jean-Michel [4 ]
Peloponese, Jean-Marie, Jr. [4 ]
机构
[1] Univ Liege, Interdisciplinary Cluster Appl Genoprote, Belgium Mol & Cellular Epigenet, Liege, Belgium
[2] Univ Quebec Montreal, Dept Sci Biol, Montreal, PQ, Canada
[3] Univ Quebec Montreal, Ctr Rech BioMed, Montreal, PQ, Canada
[4] Univ Montpellier, CNRS, Inst Rech Infectiol Montpellier, Montpellier, France
来源
FRONTIERS IN MICROBIOLOGY | 2018年 / 8卷
关键词
AP-1; HTLV-1; antisense transcription; leukemia; HBZ; JunD; LEUKEMIA-VIRUS TYPE-1; TRANSCRIPTION FACTOR AP-1; FACTOR-KAPPA-B; HTLV-1 PROVIRAL LOAD; JUN PROTO-ONCOGENE; BZIP FACTOR HBZ; C-JUN; TAX PROTEIN; ACTIVATOR PROTEIN-1; CELL-PROLIFERATION;
D O I
10.3389/fmicb.2017.02686
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies on conducting research with a molecular approach. In addition to the analysis of ATL-relevant signaling pathways, understanding the regulation of important and relevant transcription factors allows researchers to reach this fundamental objective. HTLV-1 encodes for two oncoproteins, Tax and HTLV-1 basic leucine-zipper factor, which play significant roles in the cellular transformation and the activation of the host's immune responses. Activating protein-1 (AP-1) transcription factor has been linked to cancer and neoplastic transformation ever since the first representative members of the Jun and Fos gene family were cloned and shown to be cellular homologs of viral oncogenes. AP-1 is a dimeric transcription factor composed of proteins belonging to the Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), and activating transcription factor protein families. Activation of AP-1 transcription factor family by different stimuli, such as inflammatory cytokines, stress inducers, or pathogens, results in innate and adaptive immunity. AP-1 is also involved in various cellular events including differentiation, proliferation, survival, and apoptosis. Deregulated expression of AP-1 transcription factors is implicated in various lymphomas such as classical Hodgkin lymphomas, anaplastic large cell lymphomas, diffuse large B-cell lymphomas, and adult T-cell leukemia. Here, we review the current thinking behind deregulation of the AP-1 pathway and its contribution to HTLV-induced cellular transformation.
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页数:13
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