Effect of periodontal treatment on receptor activator of NF-κB ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid

被引:40
作者
Bostanci, Nagihan [1 ]
Saygan, Buket [2 ]
Emingil, Gulnur [2 ]
Atilla, Gul [2 ]
Belibasakis, Georgios N. [1 ]
机构
[1] Univ Zurich, Ctr Dent Med, Inst Oral Biol, Fac Med, CH-8032 Zurich, Switzerland
[2] Ege Univ, Dept Periodontol, Sch Dent, Izmir, Turkey
关键词
ELISA; gingival crevicular fluid; OPG; periodontal treatment; RANKL; OPG ratio; AGGRESSIVE PERIODONTITIS; RANKL; EXPRESSION; CYTOKINE; ASSOCIATION; DISEASES; SMOKING; LESIONS; OPG;
D O I
10.1111/j.1600-051X.2011.01701.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
P>Aim Receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG) have an established role in the pathogenesis of periodontitis, which is characterized by an increased RANKL/OPG ratio. The present study aims to investigate changes of RANKL, OPG and their relative ratio in gingival crevicular fluid (GCF) of periodontitis patients after non-surgical periodontal treatment. Materials and Methods GCF was obtained from chronic periodontitis (n=14), generalized aggressive periodontitis (G-AgP; n=13) patients at baseline. The patients received scaling and root planing and were recalled after 2, 3 and 4 months for follow-up clinical examination and sampling. The total amounts and concentrations of RANKL and OPG in GCF were measured by enzyme-linked immunosorbent assay, and their relative ratio was calculated. Results The RANKL/OPG ratio remained unchanged and did not correlate with clinical parameters throughout the monitoring period, despite the improved clinical outcome. This trend was similar in both chronic and G-AgP. Conclusions Although the RANKL/OPG ratio has a potential diagnostic value for untreated periodontitis, it may not be a suitable predictor of clinically successful treatment outcome. As conventional therapy does not negatively modulate this ratio, the host could still be susceptible to further periodontal tissue destruction, warranting the consideration of adjunctive treatments.
引用
收藏
页码:428 / 433
页数:6
相关论文
共 25 条
[1]  
Armitage G C, 1999, Ann Periodontol, V4, P1, DOI 10.1902/annals.1999.4.1.1
[2]   Comparison of the clinical features of chronic and aggressive periodontitis [J].
Armitage, Gary C. ;
Cullinan, Mary P. .
PERIODONTOLOGY 2000, 2010, 53 :12-27
[3]   Comparative biology of chronic and aggressive periodontitis: introduction [J].
Armitage, Gary C. ;
Cullinan, Mary P. ;
Seymour, Gregory J. .
PERIODONTOLOGY 2000, 2010, 53 :7-11
[4]   Mechanisms and control of pathologic bone loss in periodontitis [J].
Bartold, P. Mark ;
Cantley, Melissa D. ;
Haynes, David R. .
PERIODONTOLOGY 2000, 2010, 53 :55-69
[5]   Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases:: implications of their relative ratio [J].
Bostanci, Nagihan ;
Ilgenli, Tunc ;
Emingil, Guelnur ;
Afacan, Beral ;
Han, Buket ;
Toez, Hueseyin ;
Atilla, Guel ;
Hughes, Francis J. ;
Belibasakis, Georgios N. .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2007, 34 (05) :370-376
[6]   Interleukin-17, RANKL, and Osteoprotegerin Levels in Gingival Crevicular Fluid From Smoking and Non-Smoking Patients With Chronic Periodontitis During Initial Periodontal Treatment [J].
Buduneli, Nurcan ;
Buduneli, Eralp ;
Kuetuekcueler, Necil .
JOURNAL OF PERIODONTOLOGY, 2009, 80 (08) :1274-1280
[7]   RANKL and OPG mRNA Level after Non-Surgical Periodontal Treatment [J].
Dereka, Xanthippi E. ;
Markopoulou, Cleopatra E. ;
Fanourakis, Galinos ;
Tseleni-Balafouta, Sofia ;
Vrotsos, Ioannis A. .
INFLAMMATION, 2010, 33 (03) :200-206
[8]   Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-κ B ligand, interleukin (IL)-17, IL-10 and transforming growth factor-β during the progression of chronic periodontitis [J].
Dutzan, Nicolas ;
Gamonal, Jorge ;
Silva, Augusto ;
Sanz, Mariano ;
Vernal, Rolando .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2009, 36 (05) :396-403
[9]   Adjunctive Treatment of Chronic Periodontitis With Daily Dietary Supplementation With Omega-3 Fatty Acids and Low-Dose Aspirin [J].
EI-Sharkawy, Hesham ;
Aboelsaad, Nayer ;
Eliwa, Mohamed ;
Darweesh, Mahmoud ;
Alshahat, Mohammad ;
Kantarci, Alpdogan ;
Hasturk, Hatice ;
Van Dyke, Thomas E. .
JOURNAL OF PERIODONTOLOGY, 2010, 81 (11) :1635-1643
[10]   COMPARISON OF DIFFERENT DATA ANALYSES FOR DETECTING CHANGES IN ATTACHMENT LEVEL [J].
HAFFAJEE, AD ;
SOCRANSKY, SS ;
GOODSON, JM .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1983, 10 (03) :298-310