Growth hormone therapy in adult patients: a review

被引：1
作者：
Kann, Peter Herbert [1 ]
机构：
[1] Univ Marburg, Fachbereich Med Endokrinol & Diabetol, Univ Klinikum Giessen & Marburg, D-35033 Marburg, Germany
来源：
WIENER KLINISCHE WOCHENSCHRIFT | 2011年 / 123卷 / 9-10期
关键词：
Growth hormone; hypopituitarism; therapy; quality of life; bone; lipids; BONE-MINERAL DENSITY; GH-DEFICIENT ADULTS; LONG-TERM TREATMENT; HEALTHY AGED WOMEN; QUALITY-OF-LIFE; REPLACEMENT THERAPY; BODY-COMPOSITION; FACTOR-I; PITUITARY INSUFFICIENCY; SUBSTITUTION THERAPY;
D O I：
10.1007/s00508-011-1574-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Growth hormone deficiency (GHD) can frequently be expected in hypopituitarism of adult patients. If GHD is proven by dynamic testing of the somatotrophic axis, growth hormone substitution is useful for improving quality of life, body composition, bone and lipid metabolism, and myocardial function according to the criteria of evidence-based medicine and is admitted by most national health authorities. There are no other reasonable indications for growth hormone treatment in adulthood.
引用
收藏
页码：259 / 267
页数：9
相关论文
共 90 条
[1]   Evaluation of the optimum dose of growth hormone (GH) for restoring bone mass in adult-onset GH deficiency: results from two 12-month randomized studies [J].
Abrahamsen, B ;
Hangaard, J ;
Horn, HC ;
Hansen, TB ;
Gregersen, G ;
Hansen-Nord, M ;
Vahl, N ;
Junker, P ;
Andersen, M ;
Hagen, C .
CLINICAL ENDOCRINOLOGY, 2002, 57 (02) :273-281
[2]   Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults -: a KIMS database analysis [J].
Abs, Roger ;
Feldt-Rasmussen, Ulla ;
Mattsson, Anders F. ;
Monson, John P. ;
Bengtsson, Bengt-Ake ;
Goth, Miklos I. ;
Wilton, Patrick ;
Koltowska-Haggstrom, Maria .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2006, 155 (01) :79-90
[3]   Effects of growth hormone replacement on parathyroid hormone sensitivity and bone mineral metabolism [J].
Ahmad, AM ;
Thomas, J ;
Clewes, A ;
Hopkins, MT ;
Guzder, R ;
Ibrahim, H ;
Durham, BH ;
Vora, JP ;
Fraser, WD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2860-2868
[4]   Circadian and ultradian rhythm and leptin pulsatility in adult GH deficiency: Effects of GH replacement [J].
Ahmad, AM ;
Guzder, R ;
Wallace, AM ;
Thomas, J ;
Fraser, WD ;
Vora, JP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (08) :3499-3506
[5]   Low dose recombinant human growth hormone normalizes bone metabolism and cortical bone density and improves trabecular bone density in growth hormone deficient adults without causing adverse effects [J].
Amato, G ;
Izzo, G ;
LaMontagna, G ;
Bellastella, A .
CLINICAL ENDOCRINOLOGY, 1996, 45 (01) :27-32
[6]   BODY-COMPOSITION, BONE METABOLISM, AND HEART STRUCTURE AND FUNCTION IN GROWTH-HORMONE (GH)DEFICIENT ADULTS BEFORE AND AFTER GH REPLACEMENT THERAPY AT LOW-DOSES [J].
AMATO, G ;
CARELLA, C ;
FAZIO, S ;
LAMONTAGNA, G ;
CITTADINI, A ;
SABATINI, D ;
MARCIANOMONE, C ;
SACCA, L ;
BELLASTELLA, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1671-1676
[7]   Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: A functional MRI study [J].
Arwert, LI ;
Veltman, DJ ;
Deijen, JB ;
van Dam, PS ;
Drent, ML .
NEUROENDOCRINOLOGY, 2006, 83 (01) :12-19
[8]   BONE TURNOVER AND BONE-MINERAL DENSITY IN YOUNG-ADULT PATIENTS WITH PANHYPOPITUITARISM BEFORE AND AFTER LONG-TERM GROWTH-HORMONE THERAPY [J].
BALDUCCI, R ;
TOSCANO, V ;
PASQUINO, AM ;
MANGIANTINI, A ;
MUNICCHI, G ;
ARMENISE, P ;
TERRACINA, S ;
PROSSOMARITI, G ;
BOSCHERINI, B .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 132 (01) :42-46
[9]   Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD [J].
Baroncelli, GI ;
Bertelloni, S ;
Sodini, F ;
Saggese, G .
CLINICAL ENDOCRINOLOGY, 2004, 60 (02) :175-184
[10]   Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice [J].
Bartke, A .
NEUROENDOCRINOLOGY, 2003, 78 (04) :210-216
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