EVALUATION OF ENDOTOXEMIA, SOLUBLE CD14 AND IL-1B IN DOGS WITH INTESTINAL DYSBIOSIS THAT WERE TREATED WITH PROBIOTICS: A PROSPECTIVE STUDY

被引：7

作者：

Matei, Maria-Catalina ^{[1
]}

Andrei, Sanda ^{[1
]}

Buza, Victoria ^{[1
]}

Cernea, Mihai ^{[1
]}

Dumitras, Daria Antonia ^{[1
]}

Neagu, Daniela ^{[1
]}

Rafa, Horatiu ^{[1
]}

Popovici, Cristian Paul ^{[1
]}

Pop, Raluca ^{[2
]}

Catinean, Adrian ^{[2
]}

Stefanut, Eugen ^{[3
]}

Stefanut, Laura Cristina ^{[1
]}

机构：

[1] Univ Agr Sci & Vet Med Cluj Napoca, Fac Vet Med, Cluj Napoca, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania

[3] EST Res, Bucharest, Romania

来源：

FARMACIA | 2021年 / 69卷 / 06期

关键词：

metabolic endotoxemia; intestinal dysbiosis; probiotic; CD14; IL-1; beta; dogs; MACROPHAGES;

D O I：

10.31925/farmacia.2021.6.20

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to compare the serum endotoxin levels in correlation with soluble CD14 and IL-1 beta in dogs with intestinal dysbiosis that were treated with a probiotic product containing Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici. Levels of serum endotoxin, soluble CD14 and IL-1 beta were assessed before meal consumption, and 6 and 12 h after meal consumption, both prior to initiation of probiotic treatment and after completion of 30 days of treatment. Pre-meal serum endotoxin levels decreased by 25.89% and 6 h and 12 h post-meal levels decreased by 35.00% and 44.93%, respectively, when compared to the respective pre-treatment values which correlated with a decrease in serum soluble CD14 levels, while IL-1 beta remained approximatively constant.

引用

页码：1153 / 1158

页数：6

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