A highly efficient and enantioselective synthesis of EEHP and EMHP: intermediates of PPAR agonists

被引：7

作者：

Gangar, Mukesh ^{[1
]}

Harikrishnan, M. ^{[1
]}

Goyal, Sandeep ^{[1
]}

Mungalpara, Maulik N. ^{[1
]}

Nair, Vipin A. ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Sect 67, Dept Med Chem, Sas Nagar 160062, Punjab, India

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 31期

关键词：

Chiral auxiliary; Glycolate alkylation; Stereoselectivity; EEHP; PPAR agonists; ACETATE ALDOL REACTIONS; GLYCOLATE ALKYLATION; CHIRAL AUXILIARY; FACILE SYNTHESIS; DERIVATIVES; ACID; DIHYDROTHIOURACILS;

D O I：

10.1016/j.tetlet.2016.06.093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycolate alkylation reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one auxiliary has been optimised with high yields and diastereoselectivity on substituted benzyl and allyl bromides. The standardised reaction condition was employed for the stereoselective synthesis of EEHP and EMHP intermediates of PPAR agonists. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3462 / 3467

页数：6

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