Supramolecular Drug Inclusion Complex Constructed from Tetramethyl-cucurbit[6]uril and Capecitabine via the Host-Guest Interactions

被引：3
|
作者：
Zhang, Zhirui [1 ]
Kan, Jinglan [2 ]
Feng, Huaming [3 ]
Liu, Qingyun [4 ]
Tao, Zhu [3 ]
Xiao, Xin [3 ]
机构：
[1] Ninth Peoples Hosp Chongqing, Dept Pediat, Chongqing 400700, Peoples R China
[2] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China
[3] Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China
[4] Shandong Univ Sci & Technol, Coll Chem & Environm Engn, Qingdao 266590, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 08期
关键词：
supramolecular; host-guest; cucurbit[n]uril; capecitabine; self-assembly; PROMISING PEROXIDASE MIMETICS; DELIVERY; NANOPARTICLES; SELECTIVITY; H2O2; URIL;
D O I：
10.6023/cjoc201804008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel supramolecular host-guest complex of the anticancer drug capecitabine (CAP) with symmetrical alpha,alpha',delta,delta'-tetramethyl-cucurbit[6]uril (TMeQ[6]) has been characterized using nuclear magnetic resonance spectroscopy, MALDI-TOF mass spectrometry, isothermal titration calorimetrvand fluorescence spectroscopy analyses. The result revealed that the alkyl chain of CAP is located inside the cavities of TMeQ[6], whereas the other part of CAP remains outside the portal. Our results suggest that TMeQ[6] could be a promising candidate for use as an excipient in the pharmaceutical and medical research fields.
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收藏
页码：1972 / 1976
页数：5
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