Modeling human neurodevelopmental diseases with brain organoids

被引：30

作者：

Lu, Xiaoxiang ^{[1
]}

Yang, Jiajie ^{[1
]}

Xiang, Yangfei ^{[1
]}

机构：

[1] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China

来源：

CELL REGENERATION | 2022年 / 11卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Brain organoids; Neurodevepmental diseases; Disease modeling; Stem cells; Gene editing; PLURIPOTENT STEM-CELLS; MOUSE MODEL; DOWN-SYNDROME; RETT-SYNDROME; CEREBRAL ORGANOIDS; SYNAPTIC PLASTICITY; CORTICAL-NEURONS; GENE-EXPRESSION; IN-VITRO; MICE;

D O I：

10.1186/s13619-021-00103-6

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells (hPSCs)-derived brain organoids are capable of recapitulating various features and functionalities of the human brain, allowing the investigation of intricate pathogenesis of developmental abnormalities. Over the past years, brain organoids have facilitated identifying disease-associated phenotypes and underlying mechanisms for human neurodevelopmental diseases. Integrating with more cutting-edge technologies, particularly gene editing, brain organoids further empower human disease modeling. Here, we review the latest progress in modeling human neurodevelopmental disorders with brain organoids.

引用

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