New and bioactive lignans from the fruits of Schisandra sphenanthera

被引：39

作者：

Huang, Hsin-Chan ^{[1
]}

Lin, Yu-Chi ^{[1
]}

Fazary, Ahmed Eid ^{[1
]}

Lo, I-Wen ^{[1
]}

Liaw, Chia-Ching ^{[1
]}

Huang, Yi-Zsau ^{[2
]}

Liou, Shorong-Shii ^{[3
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10764, Taiwan

[2] Natl Res Inst Chinese Med, Taipei, Taiwan

[3] Tajen Univ, Dept Pharm, Pingtung, Taiwan

来源：

FOOD CHEMISTRY | 2011年 / 128卷 / 02期

关键词：

Schisandra sphenanthera; Dibenzocyclooctadienes; Aryltetralone lignans; Anti-liver fibrosis activity; SCHIZANDRA-CHINENSIS BAILL; HEPATIC STELLATE CELLS; CONSTITUENTS;

D O I：

10.1016/j.foodchem.2011.03.030

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the ethanol extract from the fruits of Schisandra sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to 11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4, 11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：348 / 357

页数：10

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