Natural withanolides: an overview

被引：271
作者：
Chen, Li-Xia [1 ]
He, Hao [1 ]
Qiu, Feng [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
NATURAL PRODUCT REPORTS | 2011年 / 28卷 / 04期
关键词：
CHOLINESTERASE-INHIBITING WITHANOLIDES; C-28 STEROIDAL GLYCOSIDES; ALKEKENGI VAR FRANCHETI; WITHANIA-SOMNIFERA; WITHAFERIN-A; DIFFERENTIATION-INDUCERS; CYTOTOXIC WITHANOLIDES; AERIAL PARTS; SALPICHROA-ORIGANIFOLIA; SPIRANOID WITHANOLIDES;
D O I：
10.1039/c0np00045k
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Withanolides are a group of naturally occurring C-28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified. This review provides a comprehensive summary of the structural classification and distribution of these new compounds. The diverse biological and pharmacological activities of natural withanolides are also discussed based on their structural features. A total of 211 references are cited in this review.
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页码：705 / 740
页数：36
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