Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy

被引：23
作者：
Sang, Yimiao [1 ,2 ,3 ]
Gu, Xiaohong [1 ,2 ]
Pan, Lulu [1 ,2 ,4 ]
Zhang, Chunxiang [1 ,2 ,5 ,6 ]
Rong, Xing [1 ,2 ]
Wu, Tingting [1 ,2 ]
Xia, Tianhe [1 ,2 ]
Li, Yuechun [7 ,8 ]
Ge, Lisha [8 ,9 ]
Zhang, Yuanhai [1 ,2 ]
Chu, Maoping [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Childrens Heart Ctr, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Inst Cardiovasc Dev & Translat Med, Wenzhou, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Dept Pediat, Hangzhou, Zhejiang, Peoples R China
[4] Maternal & Child Hlth Care Inst, Child Hlth Manage Dept, Wenzhou, Peoples R China
[5] Univ Alabama Birmingham, Sch Med, Dept Biomed Engn, Birmingham, AL USA
[6] Univ Alabama Birmingham, Sch Engn, Birmingham, AL USA
[7] Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, Wenzhou, Peoples R China
[8] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
[9] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat, Wenzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
myocarditis; melstonin; autophagy; apoptosis; coxsackievirus B3; DEATH; REPERFUSION; PREVENTION; ACTIVATION; INFECTION; ISCHEMIA; HEART;
D O I：
10.3389/fphar.2018.01384
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis.
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页数：12
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