Rapid tumor lysis in a patient with B-cell chronic lymphocytic leukemia and lymphocytosis treated with an anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab)

被引：77
作者：
Jensen, M [1 ]
Winkler, U [1 ]
Manzke, O [1 ]
Diehl, V [1 ]
Engert, A [1 ]
机构：
[1] Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany
来源：
ANNALS OF HEMATOLOGY | 1998年 / 77卷 / 1-2期
关键词：
chronic lymphocytic leukemia; IDEC-C2B8; rituximab; tumor lysis syndrome; immunotherapy;
D O I：
10.1007/s002770050419
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this report we present a patient with B-cell chronic lymphocytic leukemia who developed an acute tumor lysis syndrome after administration of the human anti-CD20 antibody IDEC-C2B8 (RITUXIMAB) in standard dose of 375 mg/m(2). IDEC-C2B8 has been demonstrated to have only mild and tolerable side effects in patients with follicular lymphoma. In these trials patients with lymphocytosis > 5000/mu l were excluded. Physicians must be aware of this hitherto unreported phenomenon in patients with high CD20-positive blood counts.
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收藏
页码：89 / 91
页数：3
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