Cyclodextrin-based gene delivery systems

被引：328

作者：

Ortiz Mellet, Carmen ^{[2
]}

Garcia Fernandez, Jose M. ^{[1
]}

Benito, Juan M. ^{[1
]}

机构：

[1] Univ Seville, CSIC, Inst Invest Quim, E-41092 Seville, Spain

[2] Univ Seville, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 03期

关键词：

CARBOHYDRATE-CONTAINING POLYCATIONS; MOLECULAR-WEIGHT POLYETHYLENIMINE; SINGLE-STRANDED RNA; BETA-CYCLODEXTRIN; IN-VITRO; ALPHA-CYCLODEXTRINS; PLASMID DNA; INTRACELLULAR TRAFFICKING; LINEAR POLYETHYLENIMINE; CONJUGATE GENERATION-3;

D O I：

10.1039/c0cs00019a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclodextrin (CD) history has been largely dominated by their unique ability to form inclusion complexes with guests fitting in their hydrophobic cavity. Chemical funcionalization was soon recognized as a powerful mean for improving CD applications in a wide range of fields, including drug delivery, sensing or enzyme mimicking. However, 100 years after their discovery, CDs are still perceived as novel nanoobjects of undeveloped potential. This critical review provides an overview of different strategies to promote interactions between CD conjugates and genetic material by fully exploiting the inside-outside/upper-lower face anisotropy of the CD nanometric platform. Covalent modification, self-assembling and supramolecular ligation can be put forward with the ultimate goal to build artificial viruses for programmed and efficient gene therapy (222 references).

引用

页码：1586 / 1608

页数：23

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