The Therapeutic Potential of Carbon Monoxide for Inflammatory Bowel Disease

被引：36
作者：
Takagi, Tomohisa [1 ]
Uchiyama, Kazuhiko [1 ]
Naito, Yuji [1 ]
机构：
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kyoto 6028566, Japan
来源：
DIGESTION | 2015年 / 91卷 / 01期
基金：
日本学术振兴会;
关键词：
Carbon monoxide; Heme oxygenase; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; COLONY-STIMULATING FACTOR; ACID-INDUCED COLITIS; HEME OXYGENASE-1; INTESTINAL INFLAMMATION; ISCHEMIA/REPERFUSION INJURY; INHALATION; PROTECTION; MICE; INHIBITION; EXPRESSION;
D O I：
10.1159/000368765
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, are chronic, relapsing and remitting inflammatory disorders of the intestinal tract. Because the precise pathogenesis of IBD remains unclear, it is important to investigate the pathogenesis of IBD and to evaluate new anti-inflammatory strategies. Recent accumulating evidence has suggested that carbon monoxide (CO) may act as an endogenous defensive gaseous molecule to reduce inflammation and tissue injury in various organ injury models, including intestinal inflammation. Furthermore, exogenous CO administration at low concentrations is protective against intestinal inflammation. These data suggest that CO may be a novel therapeutic molecule in patients with IBD. In this review, we present what is currently known regarding the therapeutic potential of CO in intestinal inflammation. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：13 / 18
页数：6
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