NordicDB: a Nordic pool and portal for genome-wide control data

被引：8

作者：

Leu, Monica ^{[1
,2
]}

Humphreys, Keith ^{[1
]}

Surakka, Ida ^{[2
,3
]}

Rehnberg, Emil ^{[1
]}

Muilu, Juha ^{[2
]}

Rosenstrom, Paivi ^{[2
]}

Almgren, Peter ^{[4
]}

Jaaskelainen, Juha ^{[5
]}

Lifton, Richard P. ^{[6
]}

Kyvik, Kirsten Ohm ^{[7
]}

Kaprio, Jaakko ^{[2
,8
,9
]}

Pedersen, Nancy L. ^{[1
]}

Palotie, Aarno ^{[2
,10
,11
]}

Hall, Per ^{[1
]}

Gronberg, Henrik ^{[1
]}

Groop, Leif ^{[4
]}

Peltonen, Leena ^{[2
,3
,11
]}

Palmgren, Juni ^{[1
,12
]}

Ripatti, Samuli ^{[2
,3
]}

机构：

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[2] Univ Helsinki, FIMM, Inst Mol Med, Helsinki, Finland

[3] Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland

[4] Lund Univ, Ctr Diabet, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden

[5] Kuopio Univ Hosp, Dept Neurosurg, SF-70210 Kuopio, Finland

[6] Yale Univ, Howard Hughes Med Inst, Dept Genet, Chevy Chase, MD USA

[7] Univ So Denmark, Inst Publ Hlth, Dept Epidemiol, Odense Area, Denmark

[8] Natl Inst Hlth & Welf, Mental Hlth Problems & Subst Abuse Serv Unit, Helsinki, Finland

[9] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[10] Harvard & MIT, Broad Inst, Cambridge, MA USA

[11] Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England

[12] Stockholm Univ, Dept Math Stat, S-10691 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2010年 / 18卷 / 12期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

common controls; genome-wide data; Nordic Control Database; population stratification; ASSOCIATION; LOCI; STRATIFICATION; SUBSTRUCTURE; VARIANTS;

D O I：

10.1038/ejhg.2010.112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cost-efficient way to increase power in a genetic association study is to pool controls from different sources. The genotyping effort can then be directed to large case series. The Nordic Control database, NordicDB, has been set up as a unique resource in the Nordic area and the data are available for authorized users through the web portal (http://www.nordicdb.org). The current version of NordicDB pools together high-density genome-wide SNP information from similar to 5000 controls originating from Finnish, Swedish and Danish studies and shows country-specific allele frequencies for SNP markers. The genetic homogeneity of the samples was investigated using multidimensional scaling (MDS) analysis and pairwise allele frequency differences between the studies. The plot of the first two MDS components showed excellent resemblance to the geographical placement of the samples, with a clear NW-SE gradient. We advise researchers to assess the impact of population structure when incorporating NordicDB controls in association studies. This harmonized Nordic database presents a unique genome-wide resource for future genetic association studies in the Nordic countries. European Journal of Human Genetics (2010) 18, 1322-1326; doi: 10.1038/ejhg.2010.112; published online 28 July 2010

引用

页码：1322 / 1326

页数：5

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