The selective addition of water to C=C bonds; enzymes are the best chemists

被引：78

作者：

Jin, Jianfeng ^{[1
]}

Hanefeld, Ulf ^{[1
]}

机构：

[1] Delft Univ Technol, Afdeling Biotechnol, NL-2628 BL Delft, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 09期

关键词：

ENOYL-COA HYDRATASE; CONJUGATED LINOLEIC-ACID; IRON-SULFUR PROTEIN; F-SP PHASEOLI; ACETYLENE HYDRATASE; COENZYME-A; CRYSTAL-STRUCTURE; ACTIVE-SITE; PSEUDOMONAS-PSEUDOALCALIGENES; PELOBACTER-ACETYLENICUS;

D O I：

10.1039/c0cc04153j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water is the liquid of life. Nature has therefore evolved countless enzymes that catalyse the addition of water to C=C bonds, isolated or conjugated. These reactions are regio- and enantioselective, they are part of primary metabolism as well as the secondary metabolism. The enzymes that catalyse these reactions (hydratases or hydro-lyases) are applied industrially in selected cases. However, they are not generally used in the laboratory although they outperform all currently available catalytic chemical methodologies. This feature article highlights the potential that hydratases have for chemistry compared to the acid catalysed addition of water.

引用

页码：2502 / 2510

页数：9

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