The Microbiome as a Therapeutic Target for Multiple Sclerosis: Can Genetically Engineered Probiotics Treat the Disease?

被引：16

作者：

Kohl, Hannah M. ^{[1
]}

Castillo, Andrea R. ^{[1
]}

Ochoa-Reparaz, Javier ^{[1
]}

机构：

[1] Eastern Washington Univ, Dept Biol, Cheney, WA 99004 USA

来源：

DISEASES | 2020年 / 8卷 / 03期

基金：

美国国家卫生研究院;

关键词：

probiotics; microbiota; microbiome; multiple sclerosis; EAE; CENTRAL-NERVOUS-SYSTEM; CONTROLLED GENE-EXPRESSION; LACTOCOCCUS-LACTIS; GUT MICROBIOTA; T-CELLS; ORAL TOLERANCE; AUTOIMMUNE ENCEPHALOMYELITIS; BACTERIAL PEPTIDOGLYCAN; INTESTINAL INFLAMMATION; PROTEIN-PRODUCTION;

D O I：

10.3390/diseases8030033

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There is an increasing interest in the intestinal microbiota as a critical regulator of the development and function of the immune, nervous, and endocrine systems. Experimental work in animal models has provided the foundation for clinical studies to investigate associations between microbiota composition and function and human disease, including multiple sclerosis (MS). Initial work done using an animal model of brain inflammation, experimental autoimmune encephalomyelitis (EAE), suggests the existence of a microbiota-gut-brain axis connection in the context of MS, and microbiome sequence analyses reveal increases and decreases of microbial taxa in MS intestines. In this review, we discuss the impact of the intestinal microbiota on the immune system and the role of the microbiome-gut-brain axis in the neuroinflammatory disease MS. We also discuss experimental evidence supporting the hypothesis that modulating the intestinal microbiota through genetically modified probiotics may provide immunomodulatory and protective effects as a novel therapeutic approach to treat this devastating disease.

引用

页数：26

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