Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

被引：48
作者：
Ying, C
Holy, A
Hocková, D
Havlas, Z
De Clercq, E
Neyts, J
机构：
[1] Rega Inst, Louvain, Belgium
[2] Acad Sci, Inst Organ Chem & Biochem, Prague, Czech Republic
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期
关键词：
D O I：
10.1128/AAC.49.3.1177-1180.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.
引用
收藏
页码：1177 / 1180
页数：4
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