Neurons, glia, and plasticity in normal brain aging

被引：120
作者：
Finch, CE [1 ]
机构：
[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Dept Biol Sci, Los Angeles, CA 90089 USA
来源：
NEUROBIOLOGY OF AGING | 2003年 / 24卷
关键词：
brain aging; neuron loss; glial activation; Purkinje cells; oocytes;
D O I：
10.1016/S0197-4580(03)00051-4
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Early manifestations of brain aging have received much less attention than the drastic degeneration of AD and MID. During nonpathological changes of normal aging, brain systems differ in the involvement of neuron loss. Spatial learning can become impaired without evidence for neuron loss, whereas eye-blink conditioning deficits are well correlated with Purkinje neuron loss. Glial activation, in particular the increased expression of glial fibrillary acidic protein (GFAP), may be a factor in impaired synaptic plasticity. Lastly, it is discussed how developmental variations in the numbers of Purkinje cells and ovarian oocytes can be factors in outcomes of aging that are not under strict genetic control. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：S123 / S127
页数：5
相关论文
共 55 条
[1]  
[Anonymous], 2001, Functional Neurobiology of Aging
[2]  
[Anonymous], 1964, PSYCHOL AGING
[3]   Dynamic signaling between astrocytes and neurons [J].
Araque, A ;
Carmignoto, G ;
Haydon, PG .
ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :795-813
[4]  
ARNSTEN AFT, 1995, J NEUROSCI, V15, P3429
[5]   Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway [J].
Bi, RF ;
Foy, MR ;
Vouimba, RM ;
Thompson, RF ;
Baudry, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) :13391-13395
[6]   Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory [J].
Carlson, LE ;
Sherwin, BB .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2000, 7 (03) :168-177
[7]   Astroglial permissivity for neuritic outgrowth in neuron-astrocyte cocultures depends on regulation of laminin bioavailability [J].
Costa, S ;
Planchenault, T ;
Charriere-Bertrand, C ;
Mouchel, Y ;
Fages, C ;
Juliano, S ;
Lefrançois, T ;
Barlovatz-Meimon, G ;
Tardy, M .
GLIA, 2002, 37 (02) :105-113
[8]  
Finch C., 2000, CHANCE DEV AGING
[9]  
Finch Caleb E., 2002, P275
[10]   SLOW MORTALITY-RATE ACCELERATIONS DURING AGING IN SOME ANIMALS APPROXIMATE THAT OF HUMANS [J].
FINCH, CE ;
PIKE, MC ;
WITTEN, M .
SCIENCE, 1990, 249 (4971) :902-905
123456