Synthesis and characterization of thiomers of polyaspartamide type

被引：20
作者：
Bilicic, MB
Filipovic-Grcic, J
Martinac, A
Barbaric, M
Zorc, B
Cetina-Cizmek, B
Tudja, P
机构：
[1] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia
[2] Res Inst Ltd, PLIVA, Zagreb 10000, Croatia
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2005年 / 291卷 / 1-2期
关键词：
thiomer; polyaspartamide; thioglycolic acid; mucoadhesion; microparticles;
D O I：
10.1016/j.ijpharm.2004.07.058
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：211 / 219
页数：9
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