Expedient synthesis of xanthones and multi-functionalized chromones from 1,1-diacyl cyclopropanes

被引：15

作者：

French, Sarah A. ^{[1
]}

Clark, Mitchell R. ^{[1
]}

Smith, Robert J. ^{[1
]}

Brind, Thomasin ^{[1
]}

Hawkins, Bill C. ^{[1
]}

机构：

[1] Univ Otago, Dept Chem, Dunedin, New Zealand

来源：

TETRAHEDRON | 2018年 / 74卷 / 38期

关键词：

Synthetic methodology; Bioactive natural product; Chromone; Xanthone; Cyclopropane; NATURAL-PRODUCTS; REGIOSPECIFIC PREPARATION; DRUG DISCOVERY; FLAVONOIDS; SCAFFOLD; CANCER; CELLS; MRSA;

D O I：

10.1016/j.tet.2018.04.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the rapid synthesis of various cycloheptane-fused chromones and an oxepine fused flavone in 5 steps from the corresponding 2-hydroxy acetophenone. Furthermore, we describe the synthesis of xanthones, in moderate to good yield, from 2,3-disubstituted flavones using a Friedel Crafts alkylation strategy. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：5340 / 5350

页数：11