Reaction between acid N'-(2-oxo-2-phenyl-ethyl)hydrazides, acetylenic esters and alkyl isocyanides in the presence of silica sulfuric acid: One-pot synthesis of highly functionalized 2,3-dihydro-1H-pyrazoles

被引：0

作者：

Ardakani, Leili Shaker ^{[1
]}

Mosslemin, Mohammad H. ^{[1
]}

Hassanabadi, Alireza ^{[2
]}

Hashemian, Saeedeh ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Yazd Branch, Yazd, Iran

[2] Islamic Azad Univ, Dept Chem, Zahedan Branch, Zahedan, Iran

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2021年 / 196卷 / 11期

关键词：

Acetylenic esters; alkyl isocyanides; three-component reactions; acid N'-(2-oxo-2-phenyl-ethyl)hydrazides; silica sulfuric acid; 3 COMPONENT REACTION; TERT-BUTYL ISOCYANIDE; DIALKYL ACETYLENEDICARBOXYLATES; BIOLOGICAL EVALUATION; REGIOSELECTIVE SYNTHESIS; PYRAZOLES; DESIGN; NITROOLEFINS; CONSTRUCTION; DERIVATIVES;

D O I：

10.1080/10426507.2021.1949317

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactive intermediate produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by acid N'-(2-oxo-2-phenyl-ethyl)hydrazides in the presence of a catalytic amount of silica sulfuric acid (SiO2-OSO3H2) to yield highly functionalized 2,3-dihydro-1H-pyrazoles in good yields. The reaction is characterized by mild conditions and tolerance to various functional groups such as cyclohexyl, t-butyl isocyanides, and Dimethyl-, diethyl- and di-tert-butyl acetylenedicarboxylates.

引用

页码：1004 / 1009

页数：6

共 47 条

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