Topographic sleep EEG changes in the acute and chronic stage of hemispheric stroke

被引:69
作者
Poryazova, Rositsa [1 ]
Huber, Reto [2 ]
Khatami, Ramin [1 ,3 ]
Werth, Esther [1 ]
Brugger, Peter [1 ]
Barath, Krizstina [4 ]
Baumann, Christian R. [1 ]
Bassetti, Claudio L. [1 ,5 ]
机构
[1] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland
[2] Univ Childrens Hosp Zurich, Zurich, Switzerland
[3] Clin Barmelweid, Sleep Ctr, Barmelweid, Switzerland
[4] Univ Zurich Hosp, Dept Neuroradiol, CH-8091 Zurich, Switzerland
[5] Univ Bern, Inselspital, Dept Neurol, CH-3010 Bern, Switzerland
关键词
delta activity; slow-wave activity; spindle frequency range; stroke recovery; synaptic plasticity; theta activity; FOCAL CEREBRAL-ISCHEMIA; SLOW-WAVE ACTIVITY; GAMMA-HYDROXYBUTYRATE; DELTA WAVES; CORTICAL SYNCHRONIZATION; PLASTIC CHANGES; BRAIN-LESIONS; LOCAL SLEEP; HOMEOSTASIS; RAT;
D O I
10.1111/jsr.12208
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
After stroke, the injured brain undergoes extensive reorganization and reconnection. Sleep may play a role in synaptic plasticity underlying stroke recovery. To test this hypothesis, we investigated topographic sleep electroencephalographic characteristics, as a measure of brain reorganization, in the acute and chronic stages after hemispheric stroke. We studied eight patients with unilateral stroke in the supply territory of the middle cerebral artery and eight matched controls. All subjects underwent a detailed clinical examination including assessment of stroke severity, sleep habits and disturbances, anxiety and depression, and high-density electroencephalogram examination with 128 electrodes during sleep. The recordings were performed within 10days after stroke in all patients, and in six patients also 3months later. During sleep, we found higher slow-wave and theta activity over the affected hemisphere in the infarct area in the acute and chronic stage of stroke. Slow-wave, theta activity and spindle frequency range power over the affected hemisphere were lower in comparison to the non-affected side in a peri-infarct area in the patients' group, which persisted over time. Conversely, in wakefulness, only an increase of delta, theta activity and a slowing of alpha activity over the infarct area were found. Sleep slow-wave activity correlated with stroke severity and outcome. Stroke might have differential effects on the generation of delta activity in wakefulness and sleep slow waves (1-8Hz). Sleep electroencephalogram changes over both the affected and non-affected hemispheres reflect the acute dysfunction caused by stroke and the plastic changes underlying its recovery. Moreover, these changes correlate with stroke severity and outcome.
引用
收藏
页码:54 / 65
页数:12
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