Isolated Central Nervous System Chloroma as a Presenting Sign of Relapsed Pediatric Acute Lymphoblastic Leukemia

被引：2

作者：

Heath, Jessica L. ^{[1
]}

Aumann, Waitman K. ^{[2
,3
]}

Maxfield, Charles M. ^{[4
]}

Wechsler, Daniel S. ^{[2
,3
]}

机构：

[1] Univ Vermont, Div Pediat Hematol Oncol, Burlington, VT USA

[2] Childrens Healthcare Atlanta, Aflac Canc & Blood Disorders Ctr, Atlanta, GA USA

[3] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA

[4] Duke Univ, Div Pediat Radiol, Durham, NC USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 07期

关键词：

chloroma; granulocytic sarcoma; leukemia; pediatric; CNS; relapse; MINIMAL RESIDUAL DISEASE; GRANULOCYTIC SARCOMA; CLINICAL-SIGNIFICANCE; FALX MENINGIOMA; CNS RELAPSE; CHILDREN; MIMICKING; SURVIVAL;

D O I：

10.1097/MPH.0000000000001085

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Central nervous system (CNS) chloromas are an exceedingly rare presentation of CNS relapse in acute lymphoblastic leukemia (ALL). We report a relapsed ALL patient who presented with 2 separate chloromas and cerebrospinal fluid lymphoblastocytosis, and outline a treatment plan of systemic chemotherapy and CNS-directed radiation therapy. A review of the literature indicates that multiagent chemotherapy combined with CNS radiotherapy is effective, with hematopoietic stem cell transplantation used in half of reported cases. We conclude that intensive systemic multiagent chemotherapy with CNS-directed radiation therapy can be successfully used to treat relapsed pediatric ALL with CNS lymphoblastic chloroma.

引用

页码：E442 / E445

页数：4

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