Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats

被引：1

作者：

Zivna, Helena ^{[1
]}

Gradosova, Iveta ^{[1
,2
]}

Zivny, Pavel ^{[2
]}

Cermakova, Eva ^{[3
]}

Palicka, Vladimir ^{[2
]}

机构：

[1] Charles Univ Prague, Fac Med, Radioisotope Labs & Vivarium, Hradec Kralove, Czech Republic

[2] Med Fac & Univ Hosp, Inst Clin Biochem & Diagnost, Hradec Kralove, Czech Republic

[3] Charles Univ Prague, Fac Med, Comp Technol Ctr, Hradec Kralove, Czech Republic

来源：

PHARMACOLOGY | 2018年 / 102卷 / 1-2期

关键词：

Spontaneously hypertensive rat; Amlodipine; Bone metabolism; Orchidectomy; GROWTH-FACTOR-I; MINERAL DENSITY; CALCIUM-CHANNEL; OSTEOCLAST DIFFERENTIATION; OSTEOPOROSIS; ATORVASTATIN; DETERMINANT; ORCHIECTOMY; INHIBITION; OSTEOBLAST;

D O I：

10.1159/000489666

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spontaneously hypertensive rats (SHR) represent a model of essential hypertension. We studied the effect of amlodipine (AML) on bone markers, bone mineral density (BMD), and biomechanical properties of osteopenic bone induced by orchidectomy in male SHR. Rats were allocated to 3 groups and were sacrificed after 12 weeks: sham-operated control; orchidectomised control; and orchidectomised receiving a diet supplemented with AML. Indicators of bone turnover were assessed in bone homogenate, BMD was measured by dual energy X-ray absorptiometry, and the femurs were subjected to biomechanical testing. Long-term AML administration does not have a negative impact on bone metabolism and density in male SHR. (C) 2018 S. Karger AG, Basel

引用

页码：67 / 73

页数：7

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