Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

被引：18
|
作者：
Siwek, Agata [1 ]
Wujec, Monika [1 ]
Dobosz, Maria [1 ]
Jagiello-Wojtowicz, Ewa [2 ]
Chodkowska, Anna [2 ]
Kleinrok, Agnieszka [2 ]
Paneth, Piotr [3 ]
机构：
[1] Med Univ, Fac Pharm, Dept Organ Chem, PL-20081 Lublin, Poland
[2] Med Univ, Dept Toxicol, PL-20093 Lublin, Poland
[3] Acad Humanities & Econ Lodz, Dept Comp Sci, PL-90222 Lodz, Poland
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2008年 / 6卷 / 01期
关键词：
Delta(2)-1,2,4-triazoline-5-thione; CNS activity; DFT;
D O I：
10.2478/s11532-007-0058-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
By the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Delta(2)-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses.
引用
收藏
页码：47 / 53
页数：7
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