Base-Catalyzed, Three-Component Coupling of Aldehydes, Terminal Aryl Acetylenes, and Amines: Application to Synthesis of Propargylamines

被引：10
作者：
Patil, Sachin S. [1 ]
Patil, Sachin V. [1 ]
Bobade, Vivek D. [1 ]
机构：
[1] HPT Arts & RYK Sci Coll, Dept Chem, Nasik 422005, India
来源：
SYNLETT | 2011年 / 08期
关键词：
three-component coupling; aldehydes; aryl acetylenes; amines; tetraalkylammonium hydroxide; C-H ACTIVATION; SOLVENT-FREE CONDITIONS; DIMETHYLSULFOXIDE SOLUTION; ORGANIC-REACTIONS; AQUEOUS-MEDIA; EFFICIENT; ALKYNE; COPPER; WATER; SILVER;
D O I：
10.1055/s-0030-1259916
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Propargylamines are formed in high yield by three-component coupling reaction of aldehydes, terminal aryl acetylenes, and amines in DMSO in the presence of catalytic tetraalkylammonium hydroxide. This reaction does not require a transition-metal catalyst.
引用
收藏
页码：1157 / 1159
页数：3
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