Double C-H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes

被引：91
作者：
Malakar, Chandi C. [1 ]
Schmidt, Dietmar [1 ]
Conrad, Juergen [1 ]
Beifuss, Uwe [1 ]
机构：
[1] Univ Stuttgart Hohenheim, Inst Chem, D-70599 Stuttgart, Germany
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 06期
关键词：
ADENOSINE RECEPTOR ANTAGONISTS; OXIDATIVE ARYLATION; UNACTIVATED ARENES; BOND ACTIVATION; FUNCTIONALIZATION; HETEROCYCLES; HETEROARENES; ACID;
D O I：
10.1021/ol200065s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The novel Pd-catalyzed C(sp(2))-H/C(sp(2)) H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.
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收藏
页码：1378 / 1381
页数：4
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