Double C-H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes

被引：92

作者：

Malakar, Chandi C. ^{[1
]}

Schmidt, Dietmar ^{[1
]}

Conrad, Juergen ^{[1
]}

Beifuss, Uwe ^{[1
]}

机构：

[1] Univ Stuttgart Hohenheim, Inst Chem, D-70599 Stuttgart, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 06期

关键词：

ADENOSINE RECEPTOR ANTAGONISTS; OXIDATIVE ARYLATION; UNACTIVATED ARENES; BOND ACTIVATION; FUNCTIONALIZATION; HETEROCYCLES; HETEROARENES; ACID;

D O I：

10.1021/ol200065s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel Pd-catalyzed C(sp(2))-H/C(sp(2)) H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O(2) as oxidants exclusively yields C-8 arylated xanthines in a single synthetic operation.

引用

页码：1378 / 1381

页数：4

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