Nickel-Catalyzed Three-Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes

被引：112
|
作者：
Xue, Fei [1 ]
Zhao, Jin [1 ]
Hor, T. S. Andy [1 ,2 ]
Hayashi, Tamio [1 ,2 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[2] Agcy Sci Technol & Res, Inst Mat Res & Engn, Singapore 117602, Singapore
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 09期
关键词：
CROSS-COUPLING REACTION; CARBON BOND FORMATION; INTERNAL ALKYNES; STEREOSELECTIVE-SYNTHESIS; IODIDES; CARBOMETALATION; ARYLMAGNESIATION; CARBOPALLADATION; ORGANOMAGNESIUM; OLEFINS;
D O I：
10.1021/ja513166w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three-component reaction of aryl Grignard reagerits, alkynes, and aryl halides in the presence of 1 mol % of NiCl2 proceeded sequentially through carbomagnesiation of the alkyne followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetrasubstituted alkene in high yields.
引用
收藏
页码：3189 / 3192
页数：4
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