New sesquiterpene glycoside ester with antiprotozoal activity from the flowers of Calendula officinalis L

被引：4

作者：

Zaki, Ahmed A. ^{[1
,2
]}

Ashour, Ahmed A. ^{[2
]}

Qiu, Longxin ^{[1
]}

机构：

[1] Longyan Univ, Key Lab Prevent Vet Med & Biotechnol, Longyan, Peoples R China

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 23期

关键词：

Calendula; viridiflorol; antiprotozoal activity;

D O I：

10.1080/14786419.2020.1747457

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Continued chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, including one new, viridiflorol-10-O-beta-quinovopyranoside-2`-O-(3``-methyl-2``-pentenoate) (1), along with a previously reported compound viridiflorol-10-O-beta-fucopyranoside-2`-O-(3``-methyl-2``-pentenoate) (2). The new compound 1 was tested for antiprotozoal activity against Leishmania donovani Amastigote/THP1 and Trypanosoma brucei and it showed IC50 values of 3.57 and 7.84 mu g/mL, respectively, while compound 2 exhibited no activity at the highest concentration tested 10 mu g/mL.

引用

页码：5250 / 5254

页数：5

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