Prevalence and risk factors of hepatitis A among blood donors in Qazvin, central Iran

Introduction: The hepatitis A virus (HAV) is a major global health problem, especially in developing countries. Althrough children aged 5-14 years are the most infected age group, all age groups are equally affected in an HAV epidemic. The aim of this study was to determine the prevalence and related risk factors of HAV among blood donors in Qazvin, central Iran. Methods: A cross-sectional study was performed in April 2008 on a total of 351 blood donors aged 17 to 60 years. Information on demographic variables and probable risk factors was recorded. The blood samples were investigated for antibodies to HAV (HAV Ab). Data was analysed using the t-test, chi-square test and Fisher's exact test to examine the factors related to HAV Ab positivity. Results: Out of the 351 blood donors, 49.0 percent (n is 172) were regular blood donors, 94.0 percent (n is 330) were male and 71.0 percent (n is 248) were married. HAV Ab was found in 94.9 percent (n is 333) of the total sample. The prevalence of HAV Ab was higher among married and older participants. It was lower among those with a high school or vocational level of education (p is less than 0.05) than among those with a lower level of education. Conclusion: This study reveals a high prevalence of HAV Ab among adult blood donors in Qazvin, which indicates a high level of childhood contact with HAV in the area.